High Content Analysis and High Content Screening

High Content Analysis (HCA) and High Content Screening (HCS) are imaging based multi-parametric approaches of cell analysis at the single-cell level. Originally developed as a complementary technology to traditional biochemical high-throughput screening (HTS) in drug discovery, today High Content Screening is established in a far broader area of the life science space as an unbiased method of imaging multiple cellular samples.

Harmony: The image acquisition, image analysis and data management software for HCS on the Operetta

High Content Analysis and High Content Screening offer a number of advantages over traditional techniques:

• More information from cellular samples

  – fully automated imaging and unbiased image analysis exploits the full potential of microscopy, improving your lab’s throughput and productivity

• More meaningful results

  – screening can be performed under physiological and biological more relevant conditions than in a classical biochemical scenario

• More questions answered simultaneously

  – data sets are more information-rich compared to biochemical read-outs, allowing a number of questions to be asked simultaneously

PerkinElmer offers a full range of solutions for High Content Analysis and High Content Screening that can be tailored by our team of experts to meet your lab’s needs:

• Opera High Content Screening System
• Acapella Image Analysis Software
• Operetta Compact High Content Screening System
• Columbus High Volume Data Management and Analysis System
• cell::explorer Automated High Content Screening System